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Diacerein CAS 13739-02-1

Chinese name: Diacerein
Chinese Nickname-3-8-8-Diacetindiyl; Bi'anacetindibutine; 1-2-1-2-5-Dibutan-9-4,5-4,5-two stock options-2 -2
Chinese name: 1,8-Diacetoxy-3-carboxyanthraquinone
Chinese alias: diacetyl rhine; diacerein; 4,5-diacetoxyanthraquinone-2-carboxylic acid; SF 277; diacetamine;
CAS number: 13739-02-1
Molecular formula: C19H12O8
Molecular weight: 368.29400
Mass: 368.05300
Solubility: convenient second generation, second hot water, hot water, hot water.
Availability:
Quantity:
  • XJMHealth
  • XJM
  • 115
  • Diacerein 99%
  • white powder
  • HPLC
  • 13739-02-1
  • 99%
  • Kosher HALAL GMP ISO2000
  • 80-200MESH
  • Diacerein
  • Pharm grade
  • chemical synthesis
  • 2years
  • Aluminum foil bag or drum packing
  • Avaliable
  • Xi'an
  • 10 Ton/Tons per Month
  • 1kg or as your requirement.

Product Description of Diacerein:

Diacerein, also known as diacetyl dihydroanthracene carboxylic acid, 1,8-diacetyl-3-carboxyanthraquinone, dacerein, ampbitine, is a new interleukin (IL)-1 inhibitor , The chemical name is diacetyl rhein, which is an anthraquinone compound. This product can induce cartilage formation, has analgesic, anti-inflammatory and antipyretic effects, and can also significantly improve the joint function of patients with osteoarthritis, delay the course of the disease, and relieve pain. , to improve the quality of life of patients, with good safety, mainly used in clinical treatment of osteoarthritis (OA) and play an antibacterial effect. Solubility: easily soluble in dimethyl Chemicalbook sulfoxide and dimethyl acetamide; insoluble in water, methanol and chloroform. Diacerein and its active metabolite rhein reduce IL-1β production and activity by inhibiting IL-1 converting enzyme. The mechanisms of action include: 1. Inhibit the synthesis of IL-1 in synovial tissue. 2. Inhibit the expression of IL-1 receptor in chondrocytes. 3. Inhibit the activity of IL-1. 4. Inhibit the formation of metalloproteinases and peroxides such as collagenase and stromelysin. 5. Promote the synthesis of collagen and amino polysaccharides. 6. Inhibit the chemotaxis of leukocytes and stabilize lysosomes.

Diacerein does not change the cyclooxygenase activity of the kidneys and platelets, and does not inhibit the synthesis of prostaglandins, so it can be tolerated by patients with prostaglandin-dependent renal dysfunction. Oral 50mg, PPB was 99%, Tmax was 2.2h, CmaChemicalbookx was 3.2mg/L, AUC was 21.3mg·h/L, T1/2β was 4.3h. Taking with food can increase the Tmax and AUC values of this product. Adverse reactions: Diarrhea, abdominal pain and soft stools may occur in 50% of patients.

Function of Diacerein:

Diacerein and its metabolite rhein can inhibit the formation and activity of urokinase-type plasminogen activator (u-PA), directly reduce the synthesis of osteoblasts, reduce osteocalcin and promote bone mineralization.


Purpose

Application of Diacerein:

1.Widely used in new liquid crystal polymers, high-strength fibers and engineering plastics with excellent properties

2.Uses This product is an important inhibitor of IL-1 in osteoarthritis.

3.Uses A natural antioxidant, it has the functions of delaying aging, enhancing immunity, clearing sub-health state, restoring physical strength, improving energy and body immunity.

4.Uses An interleukin-1β inhibitor, which is a slow-acting anthraquinone compound.


Diacerein

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