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Hydroxypropyl-β-cyclodextrin is a chemical substance with the molecular formula (C42H70O35)-HX+(C3H7O2)X.
White powder, very soluble in water, also soluble in 50% ethanol and methanol. There is a certain relative hygroscopicity. However, the relative surface activity and hemolytic activity are relatively low. It is not irritating to muscles and is an ideal solubilizer and pharmaceutical excipient for injection.
The introduction of hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of β-cyclodextrin, and overcomes the main disadvantage of poor water solubility of β-cyclodextrin while maintaining the cyclodextrin cavity. It is one of the most in-depth and widely used cyclodextrin derivatives. Mainly used in food, medicine, cosmetics industry.
1. In the field of food and spice, it can improve the stability and long-term effect of nutritional molecules, mask or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality. The product has good solubility in water, and can be miscible with water in any proportion with a substitution degree of 4 and above, and can also be dissolved in 50% ethanol and methanol.
2. Used as stabilizer, emulsifier, deodorant, etc. in cosmetic raw materials, it can reduce the irritation of organic molecules in cosmetics to skin and mucous membrane tissues, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.
3. In the pharmaceutical industry, it is an ideal injection solubilizer and pharmaceutical excipient due to its relatively low surface activity and hemolytic activity and no irritation to muscles. It can improve the water solubility of poorly soluble drugs, increase the stability of the drugs, improve the bioavailability of the drugs, increase the efficacy of the drugs or reduce the dosage, adjust or control the release speed of the drugs, and reduce the toxic and side effects of the drugs. It can be used for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal drug delivery systems, carriers of lipophilic targeted drugs, and can also be used as protein protective agents and stabilizers.
Hydroxypropyl-β-cyclodextrin is a chemical substance with the molecular formula (C42H70O35)-HX+(C3H7O2)X.
White powder, very soluble in water, also soluble in 50% ethanol and methanol. There is a certain relative hygroscopicity. However, the relative surface activity and hemolytic activity are relatively low. It is not irritating to muscles and is an ideal solubilizer and pharmaceutical excipient for injection.
The introduction of hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of β-cyclodextrin, and overcomes the main disadvantage of poor water solubility of β-cyclodextrin while maintaining the cyclodextrin cavity. It is one of the most in-depth and widely used cyclodextrin derivatives. Mainly used in food, medicine, cosmetics industry.
1. In the field of food and spice, it can improve the stability and long-term effect of nutritional molecules, mask or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality. The product has good solubility in water, and can be miscible with water in any proportion with a substitution degree of 4 and above, and can also be dissolved in 50% ethanol and methanol.
2. Used as stabilizer, emulsifier, deodorant, etc. in cosmetic raw materials, it can reduce the irritation of organic molecules in cosmetics to skin and mucous membrane tissues, enhance the stability of active ingredients, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.
3. In the pharmaceutical industry, it is an ideal injection solubilizer and pharmaceutical excipient due to its relatively low surface activity and hemolytic activity and no irritation to muscles. It can improve the water solubility of poorly soluble drugs, increase the stability of the drugs, improve the bioavailability of the drugs, increase the efficacy of the drugs or reduce the dosage, adjust or control the release speed of the drugs, and reduce the toxic and side effects of the drugs. It can be used for oral drugs, injections, mucosal drug delivery systems (including nasal mucosa, rectum, cornea, etc.), transdermal drug delivery systems, carriers of lipophilic targeted drugs, and can also be used as protein protective agents and stabilizers.
