Milk Thistle Extract

Product Description of Milk Thistle Extract Silymarin：

Silymarin is the component with the highest content in silymarin. It has pharmacological activities such as scavenging free radicals, resisting lipid peroxidation, protecting liver cell membranes, promoting the synthesis of DNA and structural proteins in damaged liver cells, and anti-fibrosis. Metabolic toxicity to liver injury and liver cirrhosis has good curative effect, and it has been listed as a drug.

Silymarin (silymarin) is a kind of dihydroflavonol compound, which can resist liver poisoning, protect liver cells, etc. It can be used as a bile excretion agent. It has a good effect on acute and diffuse hepatitis, liver cirrhosis, metabolic toxic liver injury, recurrent pain caused by gallstones and gallstones, and cholangitis and other hepatobiliary diseases.

Function of Milk Thistle Extract Silymarin：

Hepatoprotective antioxidant effect

Silymarin can maintain the fluidity of the cell membrane by resisting lipid peroxidation, thereby protecting the liver cell membrane; it can also inhibit the release of superoxide anion from neutrophils to reduce hepatocyte damage caused by inflammatory cells. Other studies have shown that silibinin can increase the expression of superoxide dismutase (SOD) in lymphocytes of mice with chronic alcoholic liver disease, thereby playing an antioxidant role. Moreover, studies have also reported that silibinin can reduce the production of reactive oxygen species (ROS) and oxidative species such as malondialdehyde (MDA).

Anti-hepatic fibrosis

Several studies have confirmed that silymarin achieves anti-fibrotic effects by anti-oxidation and directly inhibiting the activation of hepatic stellate cells (HSC) by various cytokines.

Hepatoprotective and lipid-lowering effect

Mice experiments confirmed that silibinin can reduce the content of triglyceride (TG) in the liver and the levels of serum TG and total cholesterol (TCh). Moreover, these animal experiments also showed that liver pathology (such as steatosis, inflammation, and hepatocyte ballooning) were improved to varying degrees after silibinin intervention. Studies have also suggested that the drug can reduce the body weight of test animals.

Anti-inflammatory effect

Silibinin can reduce the levels of various pro-inflammatory cytokines, such as: IL-8, IL-6, MCP-1 and TNF-α, thereby exerting anti-inflammatory effects. This effect is achieved by inhibiting the activity of IKK-β and p50 and p65, thereby inhibiting the action of NF-κB.

Application of Silymarin：

Widely used in medicine and health care, functional food, etc.