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XJM2201
XJM
043
Toosendanin 25%
Brown yellow powder
HPLC and UV
NO
1%-98%
Kosher HALAL GMP ISO2000
80-200MESH
Toosendanin
Pharm grade or cosmetic grade and food grade
Solvent Extraction
2years
Aluminum foil bag or drum packing
Avaliable
Deciduous trees, up to 10m gray-brown bark skin, twigs gray-yellow, 2-pinnate compound leaves alternate, petioles 5-12cm long: 4-5 pairs of feathered leaves, leaflets 5-11, narrowly ovate, 4-10cm long and 2-4cm wide, apex acuminate or long acuminate, entire or rarely sparsely serrate panicle axillary; Calyx 5-6-parted; Petals 5-6, lavender; Stamens 10-L2, filaments connate into tube; Ovary superior, bottle-shaped, 6-8-locular drupe round or oblong, about 3cm in diameter, yellow or chestnut brown flowering from April to may, fruity 10-l2 month on hilly fields; Have cultivated main produce sichuan Yunnan.
Toosendanin (TSN), a triterpenoid extracted from Melia toosendan, has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. However, its anti-adipogenic effect remains unknown. Here, we found that TSN dose-dependently attenuated lipid accumulation in preadipocytes 3T3-L1 as evidenced by Oil Red O staining. TSN also significantly downregulated mRNA and protein levels of adipocytokines (adiponectin and leptin), CCAAT/enhancer binding proteins α (C/EBP-α), peroxisome proliferator-activated receptor γ (PPAR-γ), fatty acid synthase, and acetyl-CoA carboxylase in adipocytes. To understand the mechanism, we observed that TSN effectively activated Wnt/β-catenin pathway, in which TSN increased low density lipoprotein receptor related protein 6, disheveled 2, β-catenin, and cyclin D1 expression levels, while it inactivated glycogen synthase kinase 3β by enhancing its phosphorylation. Moreover, TSN reduced weight of gonadal white fat and serum triacylglycerol (TAG) content in high-fat diet (HFD)-fed mice. Interestingly, the in vivo studies also demonstrated that TSN promoted the expression of β-catenin, but accordingly repressed C/EBP-α and PPAR-γ expression in HFD-induced mice. Overall, TSN is capable of inhibiting the lipogenesis of adipocytes by activating the Wnt/β-catenin pathway, suggesting potential application of TSN as a natural anti-obesity agent.
1.Prevention and control of lepidopteran pests such as cabbage, edible insects, cabbage, night moth and beet, night moth
2 control aphids
3 Control of tetranychus mites
4. Control whitefly on string beans
5. Control of leaf miner flies on kidney beans
Deciduous trees, up to 10m gray-brown bark skin, twigs gray-yellow, 2-pinnate compound leaves alternate, petioles 5-12cm long: 4-5 pairs of feathered leaves, leaflets 5-11, narrowly ovate, 4-10cm long and 2-4cm wide, apex acuminate or long acuminate, entire or rarely sparsely serrate panicle axillary; Calyx 5-6-parted; Petals 5-6, lavender; Stamens 10-L2, filaments connate into tube; Ovary superior, bottle-shaped, 6-8-locular drupe round or oblong, about 3cm in diameter, yellow or chestnut brown flowering from April to may, fruity 10-l2 month on hilly fields; Have cultivated main produce sichuan Yunnan.
Toosendanin (TSN), a triterpenoid extracted from Melia toosendan, has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. However, its anti-adipogenic effect remains unknown. Here, we found that TSN dose-dependently attenuated lipid accumulation in preadipocytes 3T3-L1 as evidenced by Oil Red O staining. TSN also significantly downregulated mRNA and protein levels of adipocytokines (adiponectin and leptin), CCAAT/enhancer binding proteins α (C/EBP-α), peroxisome proliferator-activated receptor γ (PPAR-γ), fatty acid synthase, and acetyl-CoA carboxylase in adipocytes. To understand the mechanism, we observed that TSN effectively activated Wnt/β-catenin pathway, in which TSN increased low density lipoprotein receptor related protein 6, disheveled 2, β-catenin, and cyclin D1 expression levels, while it inactivated glycogen synthase kinase 3β by enhancing its phosphorylation. Moreover, TSN reduced weight of gonadal white fat and serum triacylglycerol (TAG) content in high-fat diet (HFD)-fed mice. Interestingly, the in vivo studies also demonstrated that TSN promoted the expression of β-catenin, but accordingly repressed C/EBP-α and PPAR-γ expression in HFD-induced mice. Overall, TSN is capable of inhibiting the lipogenesis of adipocytes by activating the Wnt/β-catenin pathway, suggesting potential application of TSN as a natural anti-obesity agent.
1.Prevention and control of lepidopteran pests such as cabbage, edible insects, cabbage, night moth and beet, night moth
2 control aphids
3 Control of tetranychus mites
4. Control whitefly on string beans
5. Control of leaf miner flies on kidney beans
