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Toosendanin Cas 58812-37-6

Product Name: Toosendanin 25%
Product alias : Toosendanin, shuguojing, lubaowei, azadirachtin
English name: Toosendanin
Source of azadirachtin plant: it is an active ingredient from root bark and bark of azadirachtin plant. Mladirachtin molecular formula: C30H38O11
Molecular weight :574.63
Properties: brown powder 
Melting point 244 ~ 245℃(decomposition). Rotation -13.1°(C =1.75, acetone). 
Soluble in pyridine, acetone, ethanol, slightly soluble in chloroform, benzene, almost insoluble in water.
Main ingredient: Toosendanin margosine
Exterior view: brown yellow powder
  • XJM2201
  • XJM
  • 043
  • Toosendanin 25%
  • Brown yellow powder
  • HPLC and UV
  • NO
  • 1%-98%
  • Kosher HALAL GMP ISO2000
  • 80-200MESH
  • Toosendanin
  • Pharm grade or cosmetic grade and food grade
  • Solvent Extraction
  • 2years
  • Aluminum foil bag or drum packing
  • Avaliable

Product Description of Toosendanin Cas  58812-37-6:

Deciduous trees, up to 10m gray-brown bark skin, twigs gray-yellow, 2-pinnate compound leaves alternate, petioles 5-12cm long: 4-5 pairs of feathered leaves, leaflets 5-11, narrowly ovate, 4-10cm long and 2-4cm wide, apex acuminate or long acuminate, entire or rarely sparsely serrate panicle axillary; Calyx 5-6-parted; Petals 5-6, lavender; Stamens 10-L2, filaments connate into tube; Ovary superior, bottle-shaped, 6-8-locular drupe round or oblong, about 3cm in diameter, yellow or chestnut brown flowering from April to may, fruity 10-l2 month on hilly fields; Have cultivated main produce sichuan Yunnan.

Function of Toosendanin Cas  58812-37-6:

Toosendanin (TSN), a triterpenoid extracted from Melia toosendan, has been reported to possess anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. However, its anti-adipogenic effect remains unknown. Here, we found that TSN dose-dependently attenuated lipid accumulation in preadipocytes 3T3-L1 as evidenced by Oil Red O staining. TSN also significantly downregulated mRNA and protein levels of adipocytokines (adiponectin and leptin), CCAAT/enhancer binding proteins α (C/EBP-α), peroxisome proliferator-activated receptor γ (PPAR-γ), fatty acid synthase, and acetyl-CoA carboxylase in adipocytes. To understand the mechanism, we observed that TSN effectively activated Wnt/β-catenin pathway, in which TSN increased low density lipoprotein receptor related protein 6, disheveled 2, β-catenin, and cyclin D1 expression levels, while it inactivated glycogen synthase kinase 3β by enhancing its phosphorylation. Moreover, TSN reduced weight of gonadal white fat and serum triacylglycerol (TAG) content in high-fat diet (HFD)-fed mice. Interestingly, the in vivo studies also demonstrated that TSN promoted the expression of β-catenin, but accordingly repressed C/EBP-α and PPAR-γ expression in HFD-induced mice. Overall, TSN is capable of inhibiting the lipogenesis of adipocytes by activating the Wnt/β-catenin pathway, suggesting potential application of TSN as a natural anti-obesity agent.

Application of Toosendanin Cas  58812-37-6:

1.Prevention and control of lepidopteran pests such as cabbage, edible insects, cabbage, night moth and beet, night moth

2 control aphids

3 Control of tetranychus mites

4. Control whitefly on string beans

5. Control of leaf miner flies on kidney beans

International Commercial Terms(Incoterms):FOB,EXW,CFR,CIF,DAT,FAS,DDP,DAP,CIP,CPT,FCA

Terms of Payment:LC.T/T.D/P.Trader assurances.western unions.moneygrams.paypal

Average Lead Time: 1-7days after receiving your payment.

Peak Season Lead Time: within 15 workdays

Off Season Lead Time: within 15 workdays

Number of Foreign Trading Staff:10 peoples

Main Markets:North America.South America.Southeast Asia.Africa.Oceania.Eastern Asia.Western Europe

Export Year:2018

Nearest Port:Shanghai

Import & Export Mode:Have Own Export License

R&D Capacity:OEM

Number. of R&D Staff:10 peoples

Number. of Production Lines:3 lines

Annual Output Value:US$5 Million - US$10 Million

Number of factory employees:more than 200peoples


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